Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples

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dc.contributor.advisorPassmore, Jo-Annen_ZA
dc.contributor.advisorGumbi, Pamelaen_ZA
dc.contributor.advisorLittle, Francescaen_ZA
dc.contributor.authorJaumdally, Shameem Zaeren_ZA
dc.date.accessioned2014-10-27T19:29:22Z
dc.date.available2014-10-27T19:29:22Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe biological correlates of protection against HIV infection remain poorly characterized, hindering the development of an effective prevention strategy. Studies of individuals who resist HIV infection or progress more slowly after being infected are important for the conception of appropriate approaches for mimicking the effective responses against HIV infection or progression. The role of immune activation and chronic inflammation in the modulation of HIV acquisition risk and/or rate of HIV disease progression has been proposed as one of the most important mechanisms determining risk and pathogenesis but is not fully understood. A state of immune quiescence has been associated with protection against HIV infection and slower disease progression. To explore potential risk factors associated with HIV transmission and HIV disease progression, this dissertation investigates the relationship between clinical and biological biomarkers and resistance to HIV infection or disease progression (including viral load, CD4 counts, cellular activation, soluble inflammatory and regulatory cytokines, and HIV co-receptor expression) in stable long-term HIV seroconcordant and serodiscordant couples.en_ZA
dc.identifier.apacitationJaumdally, S. Z. (2014). <i>Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/8796en_ZA
dc.identifier.chicagocitationJaumdally, Shameem Zaer. <i>"Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014. http://hdl.handle.net/11427/8796en_ZA
dc.identifier.citationJaumdally, S. 2014. Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jaumdally, Shameem Zaer AB - The biological correlates of protection against HIV infection remain poorly characterized, hindering the development of an effective prevention strategy. Studies of individuals who resist HIV infection or progress more slowly after being infected are important for the conception of appropriate approaches for mimicking the effective responses against HIV infection or progression. The role of immune activation and chronic inflammation in the modulation of HIV acquisition risk and/or rate of HIV disease progression has been proposed as one of the most important mechanisms determining risk and pathogenesis but is not fully understood. A state of immune quiescence has been associated with protection against HIV infection and slower disease progression. To explore potential risk factors associated with HIV transmission and HIV disease progression, this dissertation investigates the relationship between clinical and biological biomarkers and resistance to HIV infection or disease progression (including viral load, CD4 counts, cellular activation, soluble inflammatory and regulatory cytokines, and HIV co-receptor expression) in stable long-term HIV seroconcordant and serodiscordant couples. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples TI - Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples UR - http://hdl.handle.net/11427/8796 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8796
dc.identifier.vancouvercitationJaumdally SZ. Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8796en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleImpact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couplesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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