Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes

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dc.contributor.advisorJackson, W P U
dc.contributor.authorLevitt, Naomi Sharlene
dc.contributor.authorLevitt, Naomi Sharlene
dc.date.accessioned2017-08-23T13:09:00Z
dc.date.available2017-08-23T13:09:00Z
dc.date.issued1980
dc.date.updated2017-05-02T07:15:41Z
dc.description.abstractAutonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its biochemical sequelae. Recent evidence has accumulated suggesting a role for the autonomic nervous system in regulating release of a number of gastrointestinal hormones. It is therefore possible that autonomic dysfunction may be associated with altered gastrointestinal hormone release and indeed various studies have revealed abnormalities in t he release of these peptides in diabetes mellitus. The prime purpose of this thesis was to provide evidence which might contribute to an understanding of t he interrel a tionship between non insulin dependent diabetes (NIDDM), gastrointestinal hormone release and the autonomic nervous system. Thus studies to evaluate basal and stimulated release of the gastrointestinal hormones gluc a gon (IRG), pancreatic polypeptide (PP), gastrin, gastric inhibitory polypeptide (GIP) and somatostatin (SRIF-LI) have been undertaken in NIDDM. Studies were also carried out to assess whether AN may be implicated in abnormal release of these five gut hormones in diabetes and to determine if one of the hormones, PP, might be used as a marker for AN. Finally the effect of dietary fibre on glucose tolerance was studied to assess whether its effect would be altered in the presence of AN in NIDDM.
dc.identifier.apacitationLevitt, N. S., & Levitt, N. S. (1980). <i>Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology. Retrieved from http://hdl.handle.net/11427/24956en_ZA
dc.identifier.chicagocitationLevitt, Naomi Sharlene, and Naomi Sharlene Levitt. <i>"Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1980. http://hdl.handle.net/11427/24956en_ZA
dc.identifier.citationLevitt, N., Levitt, N. 1980. Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Levitt, Naomi Sharlene AU - Levitt, Naomi Sharlene AB - Autonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its biochemical sequelae. Recent evidence has accumulated suggesting a role for the autonomic nervous system in regulating release of a number of gastrointestinal hormones. It is therefore possible that autonomic dysfunction may be associated with altered gastrointestinal hormone release and indeed various studies have revealed abnormalities in t he release of these peptides in diabetes mellitus. The prime purpose of this thesis was to provide evidence which might contribute to an understanding of t he interrel a tionship between non insulin dependent diabetes (NIDDM), gastrointestinal hormone release and the autonomic nervous system. Thus studies to evaluate basal and stimulated release of the gastrointestinal hormones gluc a gon (IRG), pancreatic polypeptide (PP), gastrin, gastric inhibitory polypeptide (GIP) and somatostatin (SRIF-LI) have been undertaken in NIDDM. Studies were also carried out to assess whether AN may be implicated in abnormal release of these five gut hormones in diabetes and to determine if one of the hormones, PP, might be used as a marker for AN. Finally the effect of dietary fibre on glucose tolerance was studied to assess whether its effect would be altered in the presence of AN in NIDDM. DA - 1980 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1980 T1 - Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes TI - Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes UR - http://hdl.handle.net/11427/24956 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24956
dc.identifier.vancouvercitationLevitt NS, Levitt NS. Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1980 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/24956en_ZA
dc.language.isoeng
dc.language.isoeng
dc.publisher.departmentDivision of Endocrinology and Diabetologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherDiabetology
dc.titleStudies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes
dc.titleStudies on aspects of autonomic neuropathy in non insulin dependent Diabetes
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMD
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearch
uct.type.resourceThesis
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