Studies on immunity in the male genital tract

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dc.contributor.advisorBurgers, Wendyen_ZA
dc.contributor.authorOlivier, Abraham Jacobusen_ZA
dc.date.accessioned2015-01-04T14:20:37Z
dc.date.available2015-01-04T14:20:37Z
dc.date.issued2011en_ZA
dc.description.abstractThe male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital tract. A challenge that hampers studies at this mucosal surface is obtaining samples with sufficient immune cells. Therefore, the first aim of this study was to establish an optimised method to isolate immune cells from the male genital tract. Cellular activation and inflammation in the genital tract have important implications for both transmission and acquisition of HIV, since they provide target cells for viral replication. Thus, the second and third aim of this study was to investigate mucosal T cell activation and inflammatory cytokine profiles in semen in HIV?infected and uninfected men, and compare the immune milieu of the genital tract with the systemic compartment.en_ZA
dc.identifier.apacitationOlivier, A. J. (2011). <i>Studies on immunity in the male genital tract</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/11234en_ZA
dc.identifier.chicagocitationOlivier, Abraham Jacobus. <i>"Studies on immunity in the male genital tract."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2011. http://hdl.handle.net/11427/11234en_ZA
dc.identifier.citationOlivier, A. 2011. Studies on immunity in the male genital tract. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Olivier, Abraham Jacobus AB - The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital tract. A challenge that hampers studies at this mucosal surface is obtaining samples with sufficient immune cells. Therefore, the first aim of this study was to establish an optimised method to isolate immune cells from the male genital tract. Cellular activation and inflammation in the genital tract have important implications for both transmission and acquisition of HIV, since they provide target cells for viral replication. Thus, the second and third aim of this study was to investigate mucosal T cell activation and inflammatory cytokine profiles in semen in HIV?infected and uninfected men, and compare the immune milieu of the genital tract with the systemic compartment. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Studies on immunity in the male genital tract TI - Studies on immunity in the male genital tract UR - http://hdl.handle.net/11427/11234 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11234
dc.identifier.vancouvercitationOlivier AJ. Studies on immunity in the male genital tract. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11234en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Virologyen_ZA
dc.titleStudies on immunity in the male genital tracten_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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