Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects

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dc.contributor.advisorRodgers, Allenen_ZA
dc.contributor.authorBungane, Ntombovuyoen_ZA
dc.date.accessioned2015-05-06T07:18:11Z
dc.date.available2015-05-06T07:18:11Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractIn South Africa, the incidence of urolithiasis in the white population occurs to the same extent as in other western societies. However, in the black population, this disease is extremely rare. Differences in the gastrointestinal and renal handling of several lithogenic and antilithogenic agents in the two ethnic groups have been reported, but the rarity of kidney stone disease in the black group remains a riddle. The studies described in this thesis were undertaken to address aspects of this phenomenon. Carbohydrate and oxalate-containing dietary agents were identified as being of interest since surveys have paradoxically demonstrated that the consumption of these potentially lithogenic substances is significantly higher in the black group. The carbohydrates selected for study were glucose, sorbitol and xylitol, while the oxalatecontaining agents were rhubarb, spinach and an aqueous solution of sodium oxalate itself. Finally, taurine, which has been shown to reduce urinary glycolate and oxalate in animal models, was also selected for investigation in the two population groups. In all studies, similar protocols were adopted. These were approved by the Research and Ethics Committee of the University of Cape Town.en_ZA
dc.identifier.apacitationBungane, N. (2008). <i>Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12750en_ZA
dc.identifier.chicagocitationBungane, Ntombovuyo. <i>"Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008. http://hdl.handle.net/11427/12750en_ZA
dc.identifier.citationBungane, N. 2008. Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Bungane, Ntombovuyo AB - In South Africa, the incidence of urolithiasis in the white population occurs to the same extent as in other western societies. However, in the black population, this disease is extremely rare. Differences in the gastrointestinal and renal handling of several lithogenic and antilithogenic agents in the two ethnic groups have been reported, but the rarity of kidney stone disease in the black group remains a riddle. The studies described in this thesis were undertaken to address aspects of this phenomenon. Carbohydrate and oxalate-containing dietary agents were identified as being of interest since surveys have paradoxically demonstrated that the consumption of these potentially lithogenic substances is significantly higher in the black group. The carbohydrates selected for study were glucose, sorbitol and xylitol, while the oxalatecontaining agents were rhubarb, spinach and an aqueous solution of sodium oxalate itself. Finally, taurine, which has been shown to reduce urinary glycolate and oxalate in animal models, was also selected for investigation in the two population groups. In all studies, similar protocols were adopted. These were approved by the Research and Ethics Committee of the University of Cape Town. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects TI - Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects UR - http://hdl.handle.net/11427/12750 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12750
dc.identifier.vancouvercitationBungane N. Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12750en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleStudies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjectsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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