Infarct size and free fatty acids in the early phase of acute myocardial infarction

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dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.authorTansey, M J Ben_ZA
dc.date.accessioned2018-02-12T08:43:14Z
dc.date.available2018-02-12T08:43:14Z
dc.date.issued1980en_ZA
dc.description.abstractThe management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, 1972). The identification of any factor which may have adverse effects on the ischaemic myocardium and which is amenable to treatment would therefore have important prognostic implications. Elevation of circulating free fatty acid (FFA) concentrations is a consistent feature (Kurien and Oliver, 1966; Oliver et al, 1968) of the profound, non-specific metabolic reaction associated with the onset of AMI (Opie, 1975). The FFA rise has been correlated with the development of arrhythmias (Oliver et al, 1968) after AMI, and with the severity of ischaemic damage (Oliver et al, 1968; Gupta et al, 1969; Russell & Oliver, 1978) on clinical grounds. The method of quantifying infarct size developed by Shell et al (1972) has provided a means of correlating the degree of metabolic disturbance with extent of myocardial damage, and of assessing the benefits of metabolic interventions. The purpose of the studies reported in this thesis was to examine in detail the FFA rise in the early phase of AMI and to correlate this rise with the development of arrhythmias and other complications of AMI and with enzymatically estimated infarct size, thus leading to a more rational approach to therapeutic interventions.en_ZA
dc.identifier.apacitationTansey, M. J. B. (1980). <i>Infarct size and free fatty acids in the early phase of acute myocardial infarction</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/27505en_ZA
dc.identifier.chicagocitationTansey, M J B. <i>"Infarct size and free fatty acids in the early phase of acute myocardial infarction."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 1980. http://hdl.handle.net/11427/27505en_ZA
dc.identifier.citationTansey, M. 1980. Infarct size and free fatty acids in the early phase of acute myocardial infarction. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Tansey, M J B AB - The management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, 1972). The identification of any factor which may have adverse effects on the ischaemic myocardium and which is amenable to treatment would therefore have important prognostic implications. Elevation of circulating free fatty acid (FFA) concentrations is a consistent feature (Kurien and Oliver, 1966; Oliver et al, 1968) of the profound, non-specific metabolic reaction associated with the onset of AMI (Opie, 1975). The FFA rise has been correlated with the development of arrhythmias (Oliver et al, 1968) after AMI, and with the severity of ischaemic damage (Oliver et al, 1968; Gupta et al, 1969; Russell & Oliver, 1978) on clinical grounds. The method of quantifying infarct size developed by Shell et al (1972) has provided a means of correlating the degree of metabolic disturbance with extent of myocardial damage, and of assessing the benefits of metabolic interventions. The purpose of the studies reported in this thesis was to examine in detail the FFA rise in the early phase of AMI and to correlate this rise with the development of arrhythmias and other complications of AMI and with enzymatically estimated infarct size, thus leading to a more rational approach to therapeutic interventions. DA - 1980 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1980 T1 - Infarct size and free fatty acids in the early phase of acute myocardial infarction TI - Infarct size and free fatty acids in the early phase of acute myocardial infarction UR - http://hdl.handle.net/11427/27505 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27505
dc.identifier.vancouvercitationTansey MJB. Infarct size and free fatty acids in the early phase of acute myocardial infarction. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 1980 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27505en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMyocardial infarction - Physiopathologyen_ZA
dc.subject.otherFatty acidsen_ZA
dc.titleInfarct size and free fatty acids in the early phase of acute myocardial infarctionen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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