Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring

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dc.contributor.advisorHorsnell, Williamen_ZA
dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorDarby, Matthew Gen_ZA
dc.date.accessioned2016-07-18T12:44:42Z
dc.date.available2016-07-18T12:44:42Z
dc.date.issued2016en_ZA
dc.description.abstractIn early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to helminth infections may display T cell sensitization to endemic helminth infections and associations have been made between maternal helminth infection and altered immune responses to childhood diseases and vaccinations. This shows that helminth-modified maternal immunity may imprint on early offspring immune development in-utero or through breast milk in the form of transfer of, for example, antibodies, cytokines and lymphocytes. Our study shows that, in mice, maternal infection with the helminth Nippostrongylus brasiliensis is not only associated with a passive transfer of antigen specific antibody(IgG1) but also inherently alters offspring immunity, increasing offspring cytokine production, alveolar macrophages, lung neutrophils and B cell population development and proliferation. Pups born to N. brasiliensis exposed mothers also had increased populations of lung and spleen CD4+ cells and higher subpopulations of central memory and effector CD4+ cells compared to pups born to naive mothers.en_ZA
dc.identifier.apacitationDarby, M. G. (2016). <i>Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine. Retrieved from http://hdl.handle.net/11427/20410en_ZA
dc.identifier.chicagocitationDarby, Matthew G. <i>"Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine, 2016. http://hdl.handle.net/11427/20410en_ZA
dc.identifier.citationDarby, M. 2016. Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Darby, Matthew G AB - In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to helminth infections may display T cell sensitization to endemic helminth infections and associations have been made between maternal helminth infection and altered immune responses to childhood diseases and vaccinations. This shows that helminth-modified maternal immunity may imprint on early offspring immune development in-utero or through breast milk in the form of transfer of, for example, antibodies, cytokines and lymphocytes. Our study shows that, in mice, maternal infection with the helminth Nippostrongylus brasiliensis is not only associated with a passive transfer of antigen specific antibody(IgG1) but also inherently alters offspring immunity, increasing offspring cytokine production, alveolar macrophages, lung neutrophils and B cell population development and proliferation. Pups born to N. brasiliensis exposed mothers also had increased populations of lung and spleen CD4+ cells and higher subpopulations of central memory and effector CD4+ cells compared to pups born to naive mothers. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring TI - Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring UR - http://hdl.handle.net/11427/20410 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20410
dc.identifier.vancouvercitationDarby MG. Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20410en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherInfectious Disease and Molecular Medicineen_ZA
dc.titlePreconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspringen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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