The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorMarillier, Reece Gerraden_ZA
dc.date.accessioned2014-07-28T14:54:03Z
dc.date.available2014-07-28T14:54:03Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (leaves 117-129).
dc.description.abstractSchistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due to poor egg excretion and dysregulated granuloma formation. This resulted in increased mortality. To determine the role of AAMФ in granuloma we aimed to describe S.mansoni egg induced granuloma formation in the presence and absence of AAMФ using LysMcreIL-4Rα-/lox mice.en_ZA
dc.identifier.apacitationMarillier, R. G. (2008). <i>The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3113en_ZA
dc.identifier.chicagocitationMarillier, Reece Gerrad. <i>"The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008. http://hdl.handle.net/11427/3113en_ZA
dc.identifier.citationMarillier, R. 2008. The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Marillier, Reece Gerrad AB - Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due to poor egg excretion and dysregulated granuloma formation. This resulted in increased mortality. To determine the role of AAMФ in granuloma we aimed to describe S.mansoni egg induced granuloma formation in the presence and absence of AAMФ using LysMcreIL-4Rα-/lox mice. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation TI - The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation UR - http://hdl.handle.net/11427/3113 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3113
dc.identifier.vancouvercitationMarillier RG. The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3113en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleThe role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammationen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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