Circulating immune complexes in acute rheumatic carditis

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dc.contributor.advisorBeatty, David Williamen_ZA
dc.contributor.authorSprenger, Kenneth Johnen_ZA
dc.date.accessioned2018-01-29T07:15:15Z
dc.date.available2018-01-29T07:15:15Z
dc.date.issued1995en_ZA
dc.description.abstractThe group A beta-haemolytic streptococcus is known to be the aetiologic agent in acute rheumatic fever, but the exact pathogenesis remains obscure. A review of the histopathology of the Aschoff body suggests that the cardiac pathology is a granulomatous hypersensitivity reaction. However the streptococcus has not been found in the lesions, and the agent responsible for the granuloma has not yet been identified. Circulating immune complexes have previously been measured in some children with acute rheumatic fever. The normal or raised complement components measured by some workers in acute rheumatic fever suggests that the immune complexes may not be complement fixing. Considering that the usual assays for measuring immune complexes depend on complement fixation, the failure of the immune complexes to fix complement might produce false negative results. A physical, non-complement fixing assay (polyethylene glycol precipitation - PEG), was therefore used to measure circulating immune complexes. Results were expressed as total IgG precipitated (g/L), or as a percentage of serum IgG. Immune complexes were also measured by two complement dependent assays, a Clq binding assay (ClqBA), and conglutinin binding assay (CBA). Complexes were assayed in 15 children with acute rheumatic carditis (ARC), 11 with non-active, chronic rheumatic heart disease (CRHD), 13 with acute poststreptococcal glomerulonephritis (APSGN), and 15 normal children and adults (NORMAL). Total haemolytic complement, complement components as well as the complement breakdown product C3d, were measured.en_ZA
dc.identifier.apacitationSprenger, K. J. (1995). <i>Circulating immune complexes in acute rheumatic carditis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/27055en_ZA
dc.identifier.chicagocitationSprenger, Kenneth John. <i>"Circulating immune complexes in acute rheumatic carditis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 1995. http://hdl.handle.net/11427/27055en_ZA
dc.identifier.citationSprenger, K. 1995. Circulating immune complexes in acute rheumatic carditis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Sprenger, Kenneth John AB - The group A beta-haemolytic streptococcus is known to be the aetiologic agent in acute rheumatic fever, but the exact pathogenesis remains obscure. A review of the histopathology of the Aschoff body suggests that the cardiac pathology is a granulomatous hypersensitivity reaction. However the streptococcus has not been found in the lesions, and the agent responsible for the granuloma has not yet been identified. Circulating immune complexes have previously been measured in some children with acute rheumatic fever. The normal or raised complement components measured by some workers in acute rheumatic fever suggests that the immune complexes may not be complement fixing. Considering that the usual assays for measuring immune complexes depend on complement fixation, the failure of the immune complexes to fix complement might produce false negative results. A physical, non-complement fixing assay (polyethylene glycol precipitation - PEG), was therefore used to measure circulating immune complexes. Results were expressed as total IgG precipitated (g/L), or as a percentage of serum IgG. Immune complexes were also measured by two complement dependent assays, a Clq binding assay (ClqBA), and conglutinin binding assay (CBA). Complexes were assayed in 15 children with acute rheumatic carditis (ARC), 11 with non-active, chronic rheumatic heart disease (CRHD), 13 with acute poststreptococcal glomerulonephritis (APSGN), and 15 normal children and adults (NORMAL). Total haemolytic complement, complement components as well as the complement breakdown product C3d, were measured. DA - 1995 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1995 T1 - Circulating immune complexes in acute rheumatic carditis TI - Circulating immune complexes in acute rheumatic carditis UR - http://hdl.handle.net/11427/27055 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27055
dc.identifier.vancouvercitationSprenger KJ. Circulating immune complexes in acute rheumatic carditis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 1995 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27055en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAntigen-Antibody Complex - immunology - in infancy and childhooden_ZA
dc.subject.otherRheumatic Fever - etiology - in infancy and childhooden_ZA
dc.subject.otherRheumatic Heart Disease - immunology - in infancy and childhooden_ZA
dc.subject.otherImmune Complex Dien_ZA
dc.titleCirculating immune complexes in acute rheumatic carditisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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