Metal complexes of penicillin and cephalosporin antibiotics

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dc.contributor.advisorNassimbeni, Luigi Ren_ZA
dc.contributor.advisorLinder, P Wen_ZA
dc.contributor.advisorFazakerley, G Ven_ZA
dc.contributor.authorJackson, Graham Ellisen_ZA
dc.date.accessioned2015-02-11T14:20:00Z
dc.date.available2015-02-11T14:20:00Z
dc.date.issued1975en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe interaction between metal-ions and the penicillin and cephalosporin antibiotics have been studied in an attempt to determine both the site and mechanism of this interaction. The solution conformation of the Cu(II) and Mn(II) complexes were determined using an n.m.r, line broadening, technique. The ligands benzylpenicillin, 6-aminopenicillanic acid, cephalothin, cephalexin, ampicillin and thiaproline were used to study the effect of structural changes in the ligand on the structure of the complex. The stability constants of several metal-ions/penicillin complexes were determined potentiometrically. These were correlated with stability constants determined for several related complexes. Finally the kinetics of the Ni(II) substitution reaction with benzylpenicillin, penicilloic acid, ampicillin and thiaproline was studied.en_ZA
dc.identifier.apacitationJackson, G. E. (1975). <i>Metal complexes of penicillin and cephalosporin antibiotics</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12471en_ZA
dc.identifier.chicagocitationJackson, Graham Ellis. <i>"Metal complexes of penicillin and cephalosporin antibiotics."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1975. http://hdl.handle.net/11427/12471en_ZA
dc.identifier.citationJackson, G. 1975. Metal complexes of penicillin and cephalosporin antibiotics. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jackson, Graham Ellis AB - The interaction between metal-ions and the penicillin and cephalosporin antibiotics have been studied in an attempt to determine both the site and mechanism of this interaction. The solution conformation of the Cu(II) and Mn(II) complexes were determined using an n.m.r, line broadening, technique. The ligands benzylpenicillin, 6-aminopenicillanic acid, cephalothin, cephalexin, ampicillin and thiaproline were used to study the effect of structural changes in the ligand on the structure of the complex. The stability constants of several metal-ions/penicillin complexes were determined potentiometrically. These were correlated with stability constants determined for several related complexes. Finally the kinetics of the Ni(II) substitution reaction with benzylpenicillin, penicilloic acid, ampicillin and thiaproline was studied. DA - 1975 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1975 T1 - Metal complexes of penicillin and cephalosporin antibiotics TI - Metal complexes of penicillin and cephalosporin antibiotics UR - http://hdl.handle.net/11427/12471 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12471
dc.identifier.vancouvercitationJackson GE. Metal complexes of penicillin and cephalosporin antibiotics. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1975 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12471en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleMetal complexes of penicillin and cephalosporin antibioticsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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