The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection

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dc.contributor.advisorLecour, Sandrineen_ZA
dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.authorAlbertyn, Zulfahen_ZA
dc.date.accessioned2015-01-08T20:00:35Z
dc.date.available2015-01-08T20:00:35Z
dc.date.issued2012en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractModerate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of transcription-3(STAT-3), via mechanisms that still remain to be delineated. We therefore hypothesise that South African red and white wines confer a cardioprotective effect in relation to their melatonin content. Furthermore, we propose that the cardioprotective effect of melatonin (at a concentration found in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.en_ZA
dc.identifier.apacitationAlbertyn, Z. (2012). <i>The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/11789en_ZA
dc.identifier.chicagocitationAlbertyn, Zulfah. <i>"The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012. http://hdl.handle.net/11427/11789en_ZA
dc.identifier.citationAlbertyn, Z. 2012. The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Albertyn, Zulfah AB - Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-&#945;) and the signal transducer and activator of transcription-3(STAT-3), via mechanisms that still remain to be delineated. We therefore hypothesise that South African red and white wines confer a cardioprotective effect in relation to their melatonin content. Furthermore, we propose that the cardioprotective effect of melatonin (at a concentration found in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-&#945;/STAT-3. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection TI - The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection UR - http://hdl.handle.net/11427/11789 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11789
dc.identifier.vancouvercitationAlbertyn Z. The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11789en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMEDen_ZA
dc.titleThe role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotectionen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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