The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
Master Thesis
2012
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University of Cape Town
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Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of transcription-3(STAT-3), via mechanisms that still remain to be delineated. We therefore hypothesise that South African red and white wines confer a cardioprotective effect in relation to their melatonin content. Furthermore, we propose that the cardioprotective effect of melatonin (at a concentration found in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.
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Albertyn, Z. 2012. The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection. University of Cape Town.