Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea

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dc.contributor.authorSeaman, T
dc.contributor.authorKamatou, G P P
dc.contributor.authorVan Vuuren, S F
dc.contributor.authorVan Heerden, F R
dc.contributor.authorViljoen, A M
dc.date.accessioned2018-05-16T13:07:59Z
dc.date.available2018-05-16T13:07:59Z
dc.date.issued2007
dc.date.updated2016-01-13T10:32:06Z
dc.description.abstractExtracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The micro-organisms tested include two Gram-positive (Staphylococcus aureus and Bacillus cereus); two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacterial strains and the common pathogen responsible for tuberculosis, Mycobacterium tuberculosis. Extracts of the majority of species exhibited moderate to good antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.03 to 8.00 mg/ml. Promising activity was observed against M. tuberculosis (MIC ≤ 0.50 mg/ml) with S. radula, S. verbenaca and S. dolomitica displaying the most favourable activity (MIC: 0.10 mg/ml). The antibacterial bioassay-guided fractionation of S. chamelaeagnea resulted in the isolation of four compounds: carnosol, 7-O-methylepirosmanol, oleanolic acid and its isomer ursolic acid as the active principles against S. aureus. The in vitro antibacterial and antimycobacterial activities may support the use of Salvia species in traditional medicine to treat microbial infections.
dc.identifierhttp://dx.doi.org/10.1016/j.sajb.2007.05.001
dc.identifier.apacitationSeaman, T., Kamatou, G. P. P., Van Vuuren, S. F., Van Heerden, F. R., & Viljoen, A. M. (2007). Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea. <i>South African Journal of Botany</i>, http://hdl.handle.net/11427/28086en_ZA
dc.identifier.chicagocitationSeaman, T, G P P Kamatou, S F Van Vuuren, F R Van Heerden, and A M Viljoen "Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea." <i>South African Journal of Botany</i> (2007) http://hdl.handle.net/11427/28086en_ZA
dc.identifier.citationKamatou, G. P. P., Van Vuuren, S. F., Van Heerden, F. R., Seaman, T., & Viljoen, A. M. (2007). Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea. South African Journal of Botany, 73(4), 552-557.
dc.identifier.ris TY - AU - Seaman, T AU - Kamatou, G P P AU - Van Vuuren, S F AU - Van Heerden, F R AU - Viljoen, A M AB - Extracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The micro-organisms tested include two Gram-positive (Staphylococcus aureus and Bacillus cereus); two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacterial strains and the common pathogen responsible for tuberculosis, Mycobacterium tuberculosis. Extracts of the majority of species exhibited moderate to good antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.03 to 8.00 mg/ml. Promising activity was observed against M. tuberculosis (MIC ≤ 0.50 mg/ml) with S. radula, S. verbenaca and S. dolomitica displaying the most favourable activity (MIC: 0.10 mg/ml). The antibacterial bioassay-guided fractionation of S. chamelaeagnea resulted in the isolation of four compounds: carnosol, 7-O-methylepirosmanol, oleanolic acid and its isomer ursolic acid as the active principles against S. aureus. The in vitro antibacterial and antimycobacterial activities may support the use of Salvia species in traditional medicine to treat microbial infections. DA - 2007 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Botany LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea TI - Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea UR - http://hdl.handle.net/11427/28086 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/28086
dc.identifier.vancouvercitationSeaman T, Kamatou GPP, Van Vuuren SF, Van Heerden FR, Viljoen AM. Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea. South African Journal of Botany. 2007; http://hdl.handle.net/11427/28086.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Journal of Botany
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0254629907003079
dc.subject.other7-O-Methylepirosmanol
dc.subject.otherAntibacterial activity
dc.subject.otherAntimycobacterial activity
dc.subject.otherCarnosol
dc.subject.otherOleanolic acid
dc.subject.otherSalvia
dc.subject.otherUrsolic acid
dc.titleAntibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea
dc.typeJournal Article
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