Myocardial intermediary metabolism: with special reference to the isolated, contracting, perfused rat heart
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Studies of myocardial metabolism In vivo have been considerably advanced by the introduction of coronary sinus catheterization. By determining the coronary arterio-venous differences of various substrates, Sing and other workers (Goodale, Olson) have been able to describe the overall picture of myocardial metabollism in man and intact experimental animals. This technique dos not, however, allow adequate pinpointing of the precise pathways of cardiac metabolism in health and disease, and Bing concludes a recent review (1958) by advocating further studies using newer techniques such as radio-isotopes in a controlled in vitro system.
Opie, L.H. 1961. Myocardial intermediary metabolism : with special reference to the isolated, contracting, perfused rat heart. . ,Faculty of Health Sciences ,Department of Medicine.