The recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono- and multi-clade epidemics: implications for HIV vaccine design
Journal Article
2012
Permanent link to this Item
Authors
Journal Title
Retrovirology
Link to Journal
Journal ISSN
Volume Title
Publisher
BioMed Central Ltd
Publisher
University of Cape Town
Department
Faculty
Series
Abstract
The high level of genetic diversity of HIV-1 poses a major challenge for global vaccine development. Vaccines based on centralized sequences would minimize genetic distances to multiple clades and potentially maximize cross-reactivity. Whether reactivity of these centralized peptide reagents differs in mono- and multi-clade epidemic is unknown.
Description
Reference:
Zembe, L., Tongo, M., Ebong, E., Ngobe, E. M., Williamson, C., & Burgers, W. (2012). The recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono-and multi-clade epidemics: implications for HIV vaccine design. Retrovirology, 9(Suppl 2), P253.