Hyperglobulinaemia in the portacaval shunted rat : an experimental study.

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dc.contributor.advisorMeyers, O Len_ZA
dc.contributor.authorKeraan, Mogamat Mustaphaen_ZA
dc.date.accessioned2015-01-27T10:00:21Z
dc.date.available2015-01-27T10:00:21Z
dc.date.issued1975en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe construction of a portacaval shunt in the rat is followed by a series of characteristic phenomena : weight loss, hypo-albuminaemia, hyperglobulinaemia and an increase in the circulating antibacterial antibody levels to endogenous bowel micro-organisms. The weight loss is characterised by several weeks of decreasing weight followed by a slow progressive reversal to normality and it has its origins in postoperative anorexia. The hypo-albuminaemia to some extent parallels the weight loss but never reaches the same magnitude and it too is likely to be closely associated with anorexia. The hyperglobulinaemia which is polyclonal embraces a rise in all three major immunoglobulin classes of the rat. Evidence is presented that links this polyclonal hyperglobulinaemia to enhanced antibacterial antibodies which increase following the portacaval shunt. The shunt is believed to effectively separate the reticulo-endothelial system of the liver from the portal circulation thus allowing unlimited and constant access of antigenic material from the bowel to immunocompetent cells. Evidence is also advanced that such material from microorganisms may also stimulate other immune reactions. Similar studies in the pig are also presented and the close parallel with chronic human liver disease led to the development of an hypothesis that portal shunting of blood is the cause of hyperglobulinaemia in man. The rat is suggested as a suitable model for the experimental reproduction of human hyperglobulinaemia.en_ZA
dc.identifier.apacitationKeraan, M. M. (1975). <i>Hyperglobulinaemia in the portacaval shunted rat : an experimental study</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Biological Sciences. Retrieved from http://hdl.handle.net/11427/12324en_ZA
dc.identifier.chicagocitationKeraan, Mogamat Mustapha. <i>"Hyperglobulinaemia in the portacaval shunted rat : an experimental study."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 1975. http://hdl.handle.net/11427/12324en_ZA
dc.identifier.citationKeraan, M. 1975. Hyperglobulinaemia in the portacaval shunted rat : an experimental study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Keraan, Mogamat Mustapha AB - The construction of a portacaval shunt in the rat is followed by a series of characteristic phenomena : weight loss, hypo-albuminaemia, hyperglobulinaemia and an increase in the circulating antibacterial antibody levels to endogenous bowel micro-organisms. The weight loss is characterised by several weeks of decreasing weight followed by a slow progressive reversal to normality and it has its origins in postoperative anorexia. The hypo-albuminaemia to some extent parallels the weight loss but never reaches the same magnitude and it too is likely to be closely associated with anorexia. The hyperglobulinaemia which is polyclonal embraces a rise in all three major immunoglobulin classes of the rat. Evidence is presented that links this polyclonal hyperglobulinaemia to enhanced antibacterial antibodies which increase following the portacaval shunt. The shunt is believed to effectively separate the reticulo-endothelial system of the liver from the portal circulation thus allowing unlimited and constant access of antigenic material from the bowel to immunocompetent cells. Evidence is also advanced that such material from microorganisms may also stimulate other immune reactions. Similar studies in the pig are also presented and the close parallel with chronic human liver disease led to the development of an hypothesis that portal shunting of blood is the cause of hyperglobulinaemia in man. The rat is suggested as a suitable model for the experimental reproduction of human hyperglobulinaemia. DA - 1975 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1975 T1 - Hyperglobulinaemia in the portacaval shunted rat : an experimental study TI - Hyperglobulinaemia in the portacaval shunted rat : an experimental study UR - http://hdl.handle.net/11427/12324 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12324
dc.identifier.vancouvercitationKeraan MM. Hyperglobulinaemia in the portacaval shunted rat : an experimental study. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 1975 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12324en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Biological Sciencesen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherZoologyen_ZA
dc.titleHyperglobulinaemia in the portacaval shunted rat : an experimental study.en_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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