Investigation of local South African avipoxviruses as potential vaccine vectors

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dc.contributor.advisorWilliamson, Anna-Liseen_ZA
dc.contributor.advisorDouglass, Nicolaen_ZA
dc.contributor.authorOfferman, Kristy-Mareeen_ZA
dc.date.accessioned2015-05-26T14:14:41Z
dc.date.available2015-05-26T14:14:41Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractAvipoxviruses are large, genetically diverse DNA viruses which are particularly desirable for use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided into five groups, according to gross pathology and pock appearance on CAMs. Histopathology revealed distinct differences in epidermal and mesodermal cell proliferation, as well as immune cell infiltration, caused by the different avipoxviruses. Phylogenetic analysis was performed based on several conserved poxvirus genetic regions, corresponding to vaccinia virus (VACV) A3L (fpv167 locus, VACV P4b), G8R (fpv126 locus, VLTF-1), H3L (fpv140 locus, VACV H3L) and A11R–A12L (fpv175–176 locus). The SA isolates all grouped in clade A, either in subclade A2 or A3 of the genus Avipoxvirus, with branching patterns which differed according to the locus analysed.en_ZA
dc.identifier.apacitationOfferman, K. (2014). <i>Investigation of local South African avipoxviruses as potential vaccine vectors</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/12869en_ZA
dc.identifier.chicagocitationOfferman, Kristy-Maree. <i>"Investigation of local South African avipoxviruses as potential vaccine vectors."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2014. http://hdl.handle.net/11427/12869en_ZA
dc.identifier.citationOfferman, K. 2014. Investigation of local South African avipoxviruses as potential vaccine vectors. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Offerman, Kristy-Maree AB - Avipoxviruses are large, genetically diverse DNA viruses which are particularly desirable for use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided into five groups, according to gross pathology and pock appearance on CAMs. Histopathology revealed distinct differences in epidermal and mesodermal cell proliferation, as well as immune cell infiltration, caused by the different avipoxviruses. Phylogenetic analysis was performed based on several conserved poxvirus genetic regions, corresponding to vaccinia virus (VACV) A3L (fpv167 locus, VACV P4b), G8R (fpv126 locus, VLTF-1), H3L (fpv140 locus, VACV H3L) and A11R–A12L (fpv175–176 locus). The SA isolates all grouped in clade A, either in subclade A2 or A3 of the genus Avipoxvirus, with branching patterns which differed according to the locus analysed. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Investigation of local South African avipoxviruses as potential vaccine vectors TI - Investigation of local South African avipoxviruses as potential vaccine vectors UR - http://hdl.handle.net/11427/12869 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12869
dc.identifier.vancouvercitationOfferman K. Investigation of local South African avipoxviruses as potential vaccine vectors. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12869en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Virologyen_ZA
dc.titleInvestigation of local South African avipoxviruses as potential vaccine vectorsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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