Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis

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dc.contributor.advisorMulder, Nicolaen_ZA
dc.contributor.authorMazandu, Gaston Kuzamunuen_ZA
dc.date.accessioned2015-01-06T18:45:08Z
dc.date.available2015-01-06T18:45:08Z
dc.date.issued2010en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 126-150).en_ZA
dc.description.abstractMycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis, a leading cause of human death worldwide from infectious diseases, especially in Africa. Despite enormous advances achieved in recent years in controlling the disease, tuberculosis remains a public health challenge. The contribution of existing drugs is of immense value, but the deadly synergy of the disease with Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) and the emergence of drug resistant strains are threatening to compromise gains in tuberculosis control. In fact, the development of active tuberculosis is the outcome of the delicate balance between bacterial virulence and host resistance, which constitute two distinct and independent components. Significant progress has been made in understanding the evolution of the bacterial pathogen and its interaction with the host. The end point of these efforts is the identification of virulence factors and drug targets within the bacterium in order to develop new drugs and vaccines for the eradication of the disease.en_ZA
dc.identifier.apacitationMazandu, G. K. (2010). <i>Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine. Retrieved from http://hdl.handle.net/11427/11590en_ZA
dc.identifier.chicagocitationMazandu, Gaston Kuzamunu. <i>"Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine, 2010. http://hdl.handle.net/11427/11590en_ZA
dc.identifier.citationMazandu, G. 2010. Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mazandu, Gaston Kuzamunu AB - Mycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis, a leading cause of human death worldwide from infectious diseases, especially in Africa. Despite enormous advances achieved in recent years in controlling the disease, tuberculosis remains a public health challenge. The contribution of existing drugs is of immense value, but the deadly synergy of the disease with Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) and the emergence of drug resistant strains are threatening to compromise gains in tuberculosis control. In fact, the development of active tuberculosis is the outcome of the delicate balance between bacterial virulence and host resistance, which constitute two distinct and independent components. Significant progress has been made in understanding the evolution of the bacterial pathogen and its interaction with the host. The end point of these efforts is the identification of virulence factors and drug targets within the bacterium in order to develop new drugs and vaccines for the eradication of the disease. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis TI - Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis UR - http://hdl.handle.net/11427/11590 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11590
dc.identifier.vancouvercitationMazandu GK. Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Institute of Infectious Disease and Molecular Medicine, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11590en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherComputational Biologyen_ZA
dc.titleData integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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