Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa

dc.contributor.advisorHarley, Ericen_ZA
dc.contributor.advisorOwen, E Pen_ZA
dc.contributor.authorOlufadi, Rasaqen_ZA
dc.date.accessioned2014-07-28T08:14:06Z
dc.date.available2014-07-28T08:14:06Z
dc.date.issued2002en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractSeveral studies have shown that patients with low TPMT activity are at risk for severe and potentially fatal haematopoietic toxicity when treated with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression.en_ZA
dc.identifier.apacitationOlufadi, R. (2002). <i>Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology. Retrieved from http://hdl.handle.net/11427/2698en_ZA
dc.identifier.chicagocitationOlufadi, Rasaq. <i>"Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 2002. http://hdl.handle.net/11427/2698en_ZA
dc.identifier.citationOlufadi, R. 2002. Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Olufadi, Rasaq AB - Several studies have shown that patients with low TPMT activity are at risk for severe and potentially fatal haematopoietic toxicity when treated with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression. DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa TI - Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa UR - http://hdl.handle.net/11427/2698 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2698
dc.identifier.vancouvercitationOlufadi R. Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2698en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Chemical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemical Pathologyen_ZA
dc.titleScreening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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