Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa
Master Thesis
2002
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University of Cape Town
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Abstract
Several studies have shown that patients with low TPMT activity are at risk for severe and potentially fatal haematopoietic toxicity when treated with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression.
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Includes bibliographical references.
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Olufadi, R. 2002. Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa. University of Cape Town.