In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma

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dc.contributor.authorPotter, Paul Charlesen_ZA
dc.date.accessioned2017-12-07T07:58:42Z
dc.date.available2017-12-07T07:58:42Z
dc.date.issued1991en_ZA
dc.date.updated2017-08-07T10:59:12Z
dc.description.abstractThis thesis records a series of experiments conducted to gain further insight into factors which influence the expression, ligand binding and functional activity of the beta-2 adrenergic receptor. These studies were prompted by previous reports that the postulated beta-2 adrenergic receptor abnormality in allergic asthma could be induced, induced by autoantibodies. I established and optimised beta-2 adrenergic receptor ligand binding and functional assays in guinea pig lung membranes and then conducted an original study of beta adrenergic receptor expression in the guinea pig foetal lung. I found that beta adrenergic receptor expression in the foetal lung was dormant for 80% of the gestation period. After day 53 there was a surge in receptor expression which increased beyond term.en_ZA
dc.identifier.apacitationPotter, P. C. (1991). <i>In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology. Retrieved from http://hdl.handle.net/11427/26483en_ZA
dc.identifier.chicagocitationPotter, Paul Charles. <i>"In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 1991. http://hdl.handle.net/11427/26483en_ZA
dc.identifier.citationPotter, P. 1991. In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Potter, Paul Charles AB - This thesis records a series of experiments conducted to gain further insight into factors which influence the expression, ligand binding and functional activity of the beta-2 adrenergic receptor. These studies were prompted by previous reports that the postulated beta-2 adrenergic receptor abnormality in allergic asthma could be induced, induced by autoantibodies. I established and optimised beta-2 adrenergic receptor ligand binding and functional assays in guinea pig lung membranes and then conducted an original study of beta adrenergic receptor expression in the guinea pig foetal lung. I found that beta adrenergic receptor expression in the foetal lung was dormant for 80% of the gestation period. After day 53 there was a surge in receptor expression which increased beyond term. DA - 1991 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1991 T1 - In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma TI - In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma UR - http://hdl.handle.net/11427/26483 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26483
dc.identifier.vancouvercitationPotter PC. In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 1991 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26483en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Pulmonologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAsthma - etiologyen_ZA
dc.subject.otherLigandsen_ZA
dc.subject.otherReceptors, Adrenergic, beta - geneticsen_ZA
dc.subject.otherReceptors, Adrenergic, beta - immunologyen_ZA
dc.titleIn Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthmaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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