GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells

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dc.contributor.advisorMillar, Robert Pen_ZA
dc.contributor.authorWormald, Patricia Jen_ZA
dc.date.accessioned2018-01-31T13:44:44Z
dc.date.available2018-01-31T13:44:44Z
dc.date.issued1988en_ZA
dc.description.abstractGonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion from cultured human pituitary cells. The establishment of a human pituitary bioassay system has further made possible the investigation of the direct regulatory roles of GnRH and other neuropeptides in man. To date, such studies in man have been performed in vivo and are thus complicated by the simultaneous interactions of numerous modulators.en_ZA
dc.identifier.apacitationWormald, P. J. (1988). <i>GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology. Retrieved from http://hdl.handle.net/11427/27168en_ZA
dc.identifier.chicagocitationWormald, Patricia J. <i>"GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 1988. http://hdl.handle.net/11427/27168en_ZA
dc.identifier.citationWormald, P. 1988. GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Wormald, Patricia J AB - Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion from cultured human pituitary cells. The establishment of a human pituitary bioassay system has further made possible the investigation of the direct regulatory roles of GnRH and other neuropeptides in man. To date, such studies in man have been performed in vivo and are thus complicated by the simultaneous interactions of numerous modulators. DA - 1988 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1988 T1 - GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells TI - GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells UR - http://hdl.handle.net/11427/27168 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27168
dc.identifier.vancouvercitationWormald PJ. GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 1988 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27168en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Chemical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherGonadotropinen_ZA
dc.subject.otherPituitary hormonesen_ZA
dc.subject.otherPituitary bodyen_ZA
dc.subject.otherHormone receptorsen_ZA
dc.subject.otherGonadotrophins, Pituitary - Secretionen_ZA
dc.subject.otherNeuropeptidesen_ZA
dc.subject.otherPituitary Glanden_ZA
dc.subject.otherPituitary Hormone-Releasing Hormonesen_ZA
dc.subject.otherReceptors, Gonadoliberinen_ZA
dc.subject.otherSubsen_ZA
dc.titleGnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cellsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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