Development of an antirheumatic drug

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dc.contributor.advisorJackson, Graham Ellisen_ZA
dc.contributor.authorVoyi, Kuku Vinolia Vuyelwaen_ZA
dc.date.accessioned2016-02-22T07:20:48Z
dc.date.available2016-02-22T07:20:48Z
dc.date.issued1988en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe diamino-diamide ligands have been investigated in an attempt to develop an antirheumatic drug. The ligands N,N'-di-(2-dimethylamino)ethyloxamide and N,N'di-(2-diethylamino)ethyloxamide, were synthesised and characterised using the physical techniques, NMR, mass- and infrared spectrometry. The stability constants of the complexes of Mg, Ca, Zn and several first transition metal-ions with the ligands were determined potentiometrically. The solution conformation of the CuII complexes were determined using visible spectrophotometry. Finally the physico-chemical studies were carried out. Firstly by studying the interaction of the copper complex with albumin at the physiological pH 7.4 using visible spectrophotometry. Secondly by determining the superoxide dismutase activity of the ligand by reduction of nitrobluetetrazolium using visible spectrophotometry. Lastly the ligands and the carr, CuII, MgII and ZnII metalions were monitored in vitro using the computer blood plasma model.en_ZA
dc.identifier.apacitationVoyi, K. V. V. (1988). <i>Development of an antirheumatic drug</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17187en_ZA
dc.identifier.chicagocitationVoyi, Kuku Vinolia Vuyelwa. <i>"Development of an antirheumatic drug."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1988. http://hdl.handle.net/11427/17187en_ZA
dc.identifier.citationVoyi, K. 1988. Development of an antirheumatic drug. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Voyi, Kuku Vinolia Vuyelwa AB - The diamino-diamide ligands have been investigated in an attempt to develop an antirheumatic drug. The ligands N,N'-di-(2-dimethylamino)ethyloxamide and N,N'di-(2-diethylamino)ethyloxamide, were synthesised and characterised using the physical techniques, NMR, mass- and infrared spectrometry. The stability constants of the complexes of Mg, Ca, Zn and several first transition metal-ions with the ligands were determined potentiometrically. The solution conformation of the CuII complexes were determined using visible spectrophotometry. Finally the physico-chemical studies were carried out. Firstly by studying the interaction of the copper complex with albumin at the physiological pH 7.4 using visible spectrophotometry. Secondly by determining the superoxide dismutase activity of the ligand by reduction of nitrobluetetrazolium using visible spectrophotometry. Lastly the ligands and the carr, CuII, MgII and ZnII metalions were monitored in vitro using the computer blood plasma model. DA - 1988 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1988 T1 - Development of an antirheumatic drug TI - Development of an antirheumatic drug UR - http://hdl.handle.net/11427/17187 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17187
dc.identifier.vancouvercitationVoyi KVV. Development of an antirheumatic drug. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1988 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17187en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAntirheumatic Agentsen_ZA
dc.subject.otherRheumatism - Chemotherapyen_ZA
dc.titleDevelopment of an antirheumatic drugen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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