The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons

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dc.contributor.advisorMann, Michael Den_ZA
dc.contributor.authorAdams, Bruce Keithen_ZA
dc.date.accessioned2018-01-29T06:47:58Z
dc.date.available2018-01-29T06:47:58Z
dc.date.issued1995en_ZA
dc.description.abstractPoisoning is common and carries considerable morbidity and mortality. Two to three patients are admitted to the Emergency Unit at Groote Schuur Hospital every day with drug overdose. As absorption occurs in the small intestine the rates at which ingested poisons pass into and through the small bowel are important factors in determining the amount of poison potentially available for absorption. Although the effects of pharmacological doses of many drugs on gastric emptying and motility are known, information on the effects of higher doses is limited. I investigated patients who took overdoses of certain commonly used drugs to determine their effects on gastric emptying and motility and small intestinal transit. The study was divided into two parts. One hundred and four patients were studied in Part 1. These patients took overdoses of tricyclic antidepressants (n = 31), carbamazepine (n = 15), phenytoin (n = 12), paracetamol (n = 29) and opioid-paracetamol mixtures (n = 17). They received standard hospital management of which sorbitol was not a part. Part 2 consisted of sixty-one patients who had sorbitol added to their treatment. These patients had taken overdoses of the tricyclic antidepressants (n = 15), carbamazepine (n = 7), phenytoin (n = 8), paracetamol (n = 13) and opioid-paracetamol mixtures (n = 18). The effects of sorbitol on gastric emptying and small intestinal transit were evaluated. A third study-the paracetamol control test was done on 5 healthy volunteers. Each subject was studied twice; the first time after taking 1 G of paracetamol and the second time after no drug ingestion.en_ZA
dc.identifier.apacitationAdams, B. K. (1995). <i>The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Nuclear Medicine. Retrieved from http://hdl.handle.net/11427/27036en_ZA
dc.identifier.chicagocitationAdams, Bruce Keith. <i>"The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Nuclear Medicine, 1995. http://hdl.handle.net/11427/27036en_ZA
dc.identifier.citationAdams, B. 1995. The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Adams, Bruce Keith AB - Poisoning is common and carries considerable morbidity and mortality. Two to three patients are admitted to the Emergency Unit at Groote Schuur Hospital every day with drug overdose. As absorption occurs in the small intestine the rates at which ingested poisons pass into and through the small bowel are important factors in determining the amount of poison potentially available for absorption. Although the effects of pharmacological doses of many drugs on gastric emptying and motility are known, information on the effects of higher doses is limited. I investigated patients who took overdoses of certain commonly used drugs to determine their effects on gastric emptying and motility and small intestinal transit. The study was divided into two parts. One hundred and four patients were studied in Part 1. These patients took overdoses of tricyclic antidepressants (n = 31), carbamazepine (n = 15), phenytoin (n = 12), paracetamol (n = 29) and opioid-paracetamol mixtures (n = 17). They received standard hospital management of which sorbitol was not a part. Part 2 consisted of sixty-one patients who had sorbitol added to their treatment. These patients had taken overdoses of the tricyclic antidepressants (n = 15), carbamazepine (n = 7), phenytoin (n = 8), paracetamol (n = 13) and opioid-paracetamol mixtures (n = 18). The effects of sorbitol on gastric emptying and small intestinal transit were evaluated. A third study-the paracetamol control test was done on 5 healthy volunteers. Each subject was studied twice; the first time after taking 1 G of paracetamol and the second time after no drug ingestion. DA - 1995 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1995 T1 - The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons TI - The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons UR - http://hdl.handle.net/11427/27036 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27036
dc.identifier.vancouvercitationAdams BK. The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Nuclear Medicine, 1995 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27036en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Nuclear Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherGastric emptyingen_ZA
dc.subject.otherPoisoning - radionuclide imagingen_ZA
dc.subject.otherRadionuclide imaging - Methodsen_ZA
dc.titleThe use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisonsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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