Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria

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dc.contributor.authorMajoumouo, Michele Stella
dc.contributor.authorTincho, Marius Belmondo
dc.contributor.authorYimta, Youmbi Diane
dc.contributor.authorAdekiya, Tayo Alex
dc.contributor.authorAruleba, Raphael Taiwo
dc.contributor.authorAyawei, Nimibofa
dc.contributor.authorBoyom, Fabrice Fekam
dc.contributor.authorMorris, Thureyah
dc.date.accessioned2022-10-26T12:39:53Z
dc.date.available2022-10-26T12:39:53Z
dc.date.issued2022-07-21
dc.date.updated2022-07-25T16:32:33Z
dc.description.abstractThe absence of novel, safe, and effective bactericide is an urgent concern worldwide and remains a challenge in scientific communities. The unique proprieties of silver nanoparticles (SNPs) synthesized from plant extracts make them a suitable candidate to overcome these limitations. Herein, we synthesized SNPs from Bersama engleriana fruit (BEfr) extracts and determined their potential antibacterial activity and mode of action. SNPs were synthesized from BEfr methanolic fruit extracts at 25 and 70 ◦C, and the antibacterial effectiveness of SNPs against bacterial strains was investigated. The surface plasmon resonance peaked at 430.18 and 434.08 nm, respectively, for SNPs synthesized at 25 and 70 ◦C, confirming SNPs synthesis. BEfr-SNPs had minimum inhibitory concentrations (MIC) range of 0.234 to >50 µg/mL, which was 30-fold greater than extract alone (MIC of 500 µg/mL). BEfrSNPs-25 ◦C was potent against six bacterial strains (S. aureus, S. enterica, MRS. aureus, K. pneumonia, and S. pyogenes), with MIC range of 0.339 to 6.25 µg/mL. The mode of action of BEfr-SNPs-25 ◦C was achieved by an MRSA bacteria strain outer membrane and DNA nucleotide linkage. These results suggest that our synthesized SNPs, especially BEfr-SNPs-25 ◦C, demonstrated an enhanced antibacterial effect and could be potential candidates for bacterial infection treatment.en_US
dc.identifierdoi: 10.3390/cryst12071010
dc.identifier.apacitationMajoumouo, M. S., Tincho, M. B., Yimta, Y. D., Adekiya, T. A., Aruleba, R. T., Ayawei, N., ... Morris, T. (2022). Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria. <i>Crystals</i>, 12(7), 1010. http://hdl.handle.net/11427/36876en_ZA
dc.identifier.chicagocitationMajoumouo, Michele Stella, Marius Belmondo Tincho, Youmbi Diane Yimta, Tayo Alex Adekiya, Raphael Taiwo Aruleba, Nimibofa Ayawei, Fabrice Fekam Boyom, and Thureyah Morris "Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria." <i>Crystals</i> 12, 7. (2022): 1010. http://hdl.handle.net/11427/36876en_ZA
dc.identifier.citationMajoumouo, M.S., Tincho, M.B., Yimta, Y.D., Adekiya, T.A., Aruleba, R.T., Ayawei, N., Boyom, F.F. & Morris, T. et al. 2022. Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria. <i>Crystals.</i> 12(7):1010. http://hdl.handle.net/11427/36876en_ZA
dc.identifier.ris TY - Journal Article AU - Majoumouo, Michele Stella AU - Tincho, Marius Belmondo AU - Yimta, Youmbi Diane AU - Adekiya, Tayo Alex AU - Aruleba, Raphael Taiwo AU - Ayawei, Nimibofa AU - Boyom, Fabrice Fekam AU - Morris, Thureyah AB - The absence of novel, safe, and effective bactericide is an urgent concern worldwide and remains a challenge in scientific communities. The unique proprieties of silver nanoparticles (SNPs) synthesized from plant extracts make them a suitable candidate to overcome these limitations. Herein, we synthesized SNPs from Bersama engleriana fruit (BEfr) extracts and determined their potential antibacterial activity and mode of action. SNPs were synthesized from BEfr methanolic fruit extracts at 25 and 70 ◦C, and the antibacterial effectiveness of SNPs against bacterial strains was investigated. The surface plasmon resonance peaked at 430.18 and 434.08 nm, respectively, for SNPs synthesized at 25 and 70 ◦C, confirming SNPs synthesis. BEfr-SNPs had minimum inhibitory concentrations (MIC) range of 0.234 to >50 µg/mL, which was 30-fold greater than extract alone (MIC of 500 µg/mL). BEfrSNPs-25 ◦C was potent against six bacterial strains (S. aureus, S. enterica, MRS. aureus, K. pneumonia, and S. pyogenes), with MIC range of 0.339 to 6.25 µg/mL. The mode of action of BEfr-SNPs-25 ◦C was achieved by an MRSA bacteria strain outer membrane and DNA nucleotide linkage. These results suggest that our synthesized SNPs, especially BEfr-SNPs-25 ◦C, demonstrated an enhanced antibacterial effect and could be potential candidates for bacterial infection treatment. DA - 2022-07-21 DB - OpenUCT DP - University of Cape Town IS - 7 J1 - Crystals LK - https://open.uct.ac.za PY - 2022 T1 - Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria TI - Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria UR - http://hdl.handle.net/11427/36876 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/36876
dc.identifier.vancouvercitationMajoumouo MS, Tincho MB, Yimta YD, Adekiya TA, Aruleba RT, Ayawei N, et al. Biosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteria. Crystals. 2022;12(7):1010. http://hdl.handle.net/11427/36876.en_ZA
dc.language.isoenen_US
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_US
dc.publisher.facultyFaculty of Scienceen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceCrystalsen_US
dc.source.journalissue7en_US
dc.source.journalvolume12en_US
dc.source.pagination1010en_US
dc.source.urihttps://www.mdpi.com/journal/crystals
dc.titleBiosynthesis of Silver Nanoparticles Using Bersama engleriana Fruits Extracts and Their Potential Inhibitory Effect on Resistant Bacteriaen_US
dc.typeJournal Articleen_US
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