Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species

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dc.contributor.advisorLecour, Sandrineen_ZA
dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.authorLacerda, Lydiaen_ZA
dc.date.accessioned2014-07-29T09:04:19Z
dc.date.available2014-07-29T09:04:19Z
dc.date.issued2005en_ZA
dc.descriptionIncludes bibliographical references (leaves 73-89).
dc.description.abstractTumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria.en_ZA
dc.identifier.apacitationLacerda, L. (2005). <i>Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3414en_ZA
dc.identifier.chicagocitationLacerda, Lydia. <i>"Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2005. http://hdl.handle.net/11427/3414en_ZA
dc.identifier.citationLacerda, L. 2005. Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Lacerda, Lydia AB - Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria. DA - 2005 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species TI - Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species UR - http://hdl.handle.net/11427/3414 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3414
dc.identifier.vancouvercitationLacerda L. Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2005 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3414en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleSignalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen speciesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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