Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species

Master Thesis

2005

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http://hdl.handle.net/11427/3414
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thesis_hsf_2005_lacerda_l 2.pdf (12.73 MB)
Authors
Lacerda, Lydia
Supervisors
Lecour, Sandrine
Opie, Lionel H
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University of Cape Town

Department
Department of Medicine
Faculty
Faculty of Health Sciences
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Abstract
Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria.
Description

Includes bibliographical references (leaves 73-89).

Keywords
Medicine

Reference:

Lacerda, L. 2005. Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species. University of Cape Town.

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