Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol
Doctoral Thesis
2003
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University of Cape Town
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Abstract
Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents.
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Bibliography: leaves 175-182.
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Mudzunga, T. 2003. Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol. University of Cape Town.