USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions

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dc.contributor.authorBaron, Yorannen_ZA
dc.contributor.authorCorre, Sébastienen_ZA
dc.contributor.authorMouchet, Nicolasen_ZA
dc.contributor.authorVaulont, Sophieen_ZA
dc.contributor.authorPrince, Sharonen_ZA
dc.contributor.authorGalibert, Marie-Dominiqueen_ZA
dc.date.accessioned2015-11-18T07:10:41Z
dc.date.available2015-11-18T07:10:41Z
dc.date.issued2012en_ZA
dc.description.abstractAuthor Summary UV is responsible for DNA damage and genetic alterations of key players of the Nucleotide Excision Repair (NER) machinery promote the development of UV-induced skin cancers. The NER is the major DNA-repair process involved in the recognition and removal of UV-mediated DNA damage. Different factors participating in this DNA repair are essential, and their mutations are associated with severe genetic diseases such as Cockayne Syndrome and Xeroderma Pigmentosum. Here, we show for the first time that the specific regulation of expression in response to UV of two NER factors CSA and HR23A is required to efficiently remove DNA lesions and to maintain genomic stability. We also implicate the USF-1 transcription factor in the regulation of the expression of these factors using in vitro and in vivo models. This finding is particularly important because UV is the major cause of skin cancers and dramatically compromises patients with highly sensitive genetic diseases.en_ZA
dc.identifier.apacitationBaron, Y., Corre, S., Mouchet, N., Vaulont, S., Prince, S., & Galibert, M. (2012). USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. <i>PLOS Genetics</i>, http://hdl.handle.net/11427/15138en_ZA
dc.identifier.chicagocitationBaron, Yorann, Sébastien Corre, Nicolas Mouchet, Sophie Vaulont, Sharon Prince, and Marie-Dominique Galibert "USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions." <i>PLOS Genetics</i> (2012) http://hdl.handle.net/11427/15138en_ZA
dc.identifier.citationBaron, Y., Corre, S., Mouchet, N., Vaulont, S., Prince, S., & Galibert, M. D. (2012). USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLoS Genet, 8(1), 26. doi:10.1371/journal.pgen.1002470en_ZA
dc.identifier.ris TY - Journal Article AU - Baron, Yorann AU - Corre, Sébastien AU - Mouchet, Nicolas AU - Vaulont, Sophie AU - Prince, Sharon AU - Galibert, Marie-Dominique AB - Author Summary UV is responsible for DNA damage and genetic alterations of key players of the Nucleotide Excision Repair (NER) machinery promote the development of UV-induced skin cancers. The NER is the major DNA-repair process involved in the recognition and removal of UV-mediated DNA damage. Different factors participating in this DNA repair are essential, and their mutations are associated with severe genetic diseases such as Cockayne Syndrome and Xeroderma Pigmentosum. Here, we show for the first time that the specific regulation of expression in response to UV of two NER factors CSA and HR23A is required to efficiently remove DNA lesions and to maintain genomic stability. We also implicate the USF-1 transcription factor in the regulation of the expression of these factors using in vitro and in vivo models. This finding is particularly important because UV is the major cause of skin cancers and dramatically compromises patients with highly sensitive genetic diseases. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pgen.1002470 DP - University of Cape Town J1 - PLOS Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions TI - USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions UR - http://hdl.handle.net/11427/15138 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15138
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.1002470
dc.identifier.vancouvercitationBaron Y, Corre S, Mouchet N, Vaulont S, Prince S, Galibert M. USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLOS Genetics. 2012; http://hdl.handle.net/11427/15138.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2012 Baron et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLOS Geneticsen_ZA
dc.source.urihttp://journals.plos.org/plosgeneticsen_ZA
dc.subject.otherGene expressionen_ZA
dc.subject.otherDNA damageen_ZA
dc.subject.otherKeratinocytesen_ZA
dc.subject.otherGene regulationen_ZA
dc.subject.otherSmall interfering RNAsen_ZA
dc.subject.otherTranscription factorsen_ZA
dc.subject.otherDNA repairen_ZA
dc.subject.otherImmunoprecipitationen_ZA
dc.titleUSF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesionsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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