A study of aminolaevulinic acid synthase

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dc.contributor.advisorKirsch, Ralphen_ZA
dc.contributor.advisorMeissner, Peteren_ZA
dc.contributor.authorNahman, Carolyn Joyen_ZA
dc.date.accessioned2014-07-29T09:08:47Z
dc.date.available2014-07-29T09:08:47Z
dc.date.issued2001en_ZA
dc.descriptionBibliography: leaves 203-245.
dc.description.abstractDelta-aminolaevulinic acid synthase (ALAS) is the first enzyme in the haem biosynthetic pathway, and in mammals is present in two isoforms - differing in regulation and encoded for on different chromosomes. The hepatic form is up-regulated in states of haem deficiency and thus implicated in the acute attack of porphyria. Given the large number of patients who suffer from an acute form porphyria in South Africa the regulation of the human hepatic form of the enzyme is of considerable interest.en_ZA
dc.identifier.apacitationNahman, C. J. (2001). <i>A study of aminolaevulinic acid synthase</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3439en_ZA
dc.identifier.chicagocitationNahman, Carolyn Joy. <i>"A study of aminolaevulinic acid synthase."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2001. http://hdl.handle.net/11427/3439en_ZA
dc.identifier.citationNahman, C. 2001. A study of aminolaevulinic acid synthase. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Nahman, Carolyn Joy AB - Delta-aminolaevulinic acid synthase (ALAS) is the first enzyme in the haem biosynthetic pathway, and in mammals is present in two isoforms - differing in regulation and encoded for on different chromosomes. The hepatic form is up-regulated in states of haem deficiency and thus implicated in the acute attack of porphyria. Given the large number of patients who suffer from an acute form porphyria in South Africa the regulation of the human hepatic form of the enzyme is of considerable interest. DA - 2001 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2001 T1 - A study of aminolaevulinic acid synthase TI - A study of aminolaevulinic acid synthase UR - http://hdl.handle.net/11427/3439 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3439
dc.identifier.vancouvercitationNahman CJ. A study of aminolaevulinic acid synthase. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2001 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3439en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleA study of aminolaevulinic acid synthaseen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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