The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning
Doctoral Thesis
2006
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University of Cape Town
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Abstract
Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial infarction. This protective phenomenon that lessens myocardial infarction can be mimicked by the cytokine tumor necrosis factor alpha (TNFα) but the signalling pathways involved still remain unclear.
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Includes bibliographical references (leaves 150-177).
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Suleman, N. 2006. The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning. University of Cape Town.