Cigarette smoke and human pulmonary immune responses to mycobacteria

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dc.contributor.advisorDheda, Keertanen_ZA
dc.contributor.advisorBateman, Eric Den_ZA
dc.contributor.authorVan Zyl-Smit, Richard Nellisen_ZA
dc.date.accessioned2015-01-03T05:36:35Z
dc.date.available2015-01-03T05:36:35Z
dc.date.issued2011en_ZA
dc.description.abstractRecent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant reductions in the production of key cytokines implicated in defences against mycobacteria were observed, not attributable to impairment of mycobacterial uptake by cigarette smoke extract exposure. Furthermore, control of intracellular mycobacterial growth was impaired by cigarette smoke extract exposure.en_ZA
dc.identifier.apacitationVan Zyl-Smit, R. N. (2011). <i>Cigarette smoke and human pulmonary immune responses to mycobacteria</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/11103en_ZA
dc.identifier.chicagocitationVan Zyl-Smit, Richard Nellis. <i>"Cigarette smoke and human pulmonary immune responses to mycobacteria."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2011. http://hdl.handle.net/11427/11103en_ZA
dc.identifier.citationVan Zyl-Smit, R. 2011. Cigarette smoke and human pulmonary immune responses to mycobacteria. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van Zyl-Smit, Richard Nellis AB - Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant reductions in the production of key cytokines implicated in defences against mycobacteria were observed, not attributable to impairment of mycobacterial uptake by cigarette smoke extract exposure. Furthermore, control of intracellular mycobacterial growth was impaired by cigarette smoke extract exposure. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Cigarette smoke and human pulmonary immune responses to mycobacteria TI - Cigarette smoke and human pulmonary immune responses to mycobacteria UR - http://hdl.handle.net/11427/11103 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11103
dc.identifier.vancouvercitationVan Zyl-Smit RN. Cigarette smoke and human pulmonary immune responses to mycobacteria. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11103en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleCigarette smoke and human pulmonary immune responses to mycobacteriaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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