Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide

Simple item page
dc.contributor.advisorVinik, A Ien_ZA
dc.contributor.authorSive, Alan Avromen_ZA
dc.date.accessioned2017-12-11T10:15:53Z
dc.date.available2017-12-11T10:15:53Z
dc.date.issued1982en_ZA
dc.description.abstractPancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus.en_ZA
dc.identifier.apacitationSive, A. A. (1982). <i>Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology. Retrieved from http://hdl.handle.net/11427/26525en_ZA
dc.identifier.chicagocitationSive, Alan Avrom. <i>"Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1982. http://hdl.handle.net/11427/26525en_ZA
dc.identifier.citationSive, A. 1982. Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Sive, Alan Avrom AB - Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus. DA - 1982 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1982 T1 - Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide TI - Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide UR - http://hdl.handle.net/11427/26525 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26525
dc.identifier.vancouvercitationSive AA. Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Endocrinology and Diabetology, 1982 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26525en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Endocrinology and Diabetologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherDiabetologyen_ZA
dc.titleStudies on aspects of the physiology and pathophysiology of pancreatic polypeptideen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_1982_sive_alan_avrom.pdf
Size:
31.58 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral