Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
Master Thesis
2003
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University of Cape Town
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Abstract
Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate.
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Bibliography: leaves 81-83.
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Mabizela, N. 2003. Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery. University of Cape Town.