Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorMabizela, Nontobekoen_ZA
dc.date.accessioned2014-08-13T14:26:54Z
dc.date.available2014-08-13T14:26:54Z
dc.date.issued2003en_ZA
dc.descriptionBibliography: leaves 81-83.en_ZA
dc.description.abstractBaylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate.en_ZA
dc.identifier.apacitationMabizela, N. (2003). <i>Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6325en_ZA
dc.identifier.chicagocitationMabizela, Nontobeko. <i>"Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2003. http://hdl.handle.net/11427/6325en_ZA
dc.identifier.citationMabizela, N. 2003. Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mabizela, Nontobeko AB - Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate. DA - 2003 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2003 T1 - Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery TI - Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery UR - http://hdl.handle.net/11427/6325 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6325
dc.identifier.vancouvercitationMabizela N. Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2003 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6325en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleUtilization of the Baylis-Hillman and related reactions in antiparasitic drug discoveryen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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