The association of the secondary DNA-binding site of linker histone H5 in a nucleosome
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University of Cape Town
In order to understand the role of linker histones in the formation of the 30-run chromatin fibre as well as their role in transcriptional repression, it is essential to know their location on the nucleosome. In this study, we have modelled the location of the globular domain of chicken linker histone HS (GHS) on the nuc1eosome. The primary DNA binding site of GH5 was modelled by homology to the co-crystal structure of the E. coli CAP-DNA complex.
Bibliography: leaves 153-170.
Koorsen, G. 2001. The association of the secondary DNA-binding site of linker histone H5 in a nucleosome. University of Cape Town.