Exercise induced neuroprotection in spontaneuosly running rats

Doctoral Thesis

2007

Permanent link to this Item
http://hdl.handle.net/11427/3263
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thesis_hsf_2007_mabandla_mv.pdf (13.04 MB)
Authors
Mabandla, Musa Vuyisile
Supervisors
Gibson, Alan St Clair
Russell, Vivienue A
Journal Title
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Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Department of Human Biology
Faculty
Faculty of Health Sciences
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Abstract
We investigated the effects of voluntary exercise on neuroprotection after unilateral lesions with 6-hydroxydopamine. Rats were divided into runners (had access to running wheel) and non-runners (their running wheels were immobilised). Two weeks after injection of the neurotoxin, the rats were injected with apomorphine and the number of ipsilateral and contralateral rotations was counted with contralateral rotations of greater than 150 considered to represent striatal dopamine neuron destruction of 70% or above.
Description

Includes bibliographical references (p. 182-205).

Keywords
Human Biology

Reference:

Mabandla, M. 2007. Exercise induced neuroprotection in spontaneuosly running rats. University of Cape Town.

Collections
PhD / Doctoral