The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase

Doctoral Thesis

1980

Permanent link to this Item
http://hdl.handle.net/11427/27512
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thesis_hsf_1980_manca_veronica.pdf (8.38 MB)
Authors
Manca, Veronica
Supervisors
Harrison, Gaisford Gerald
Ivanetich, Kathryn M
Journal Title
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Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Medical Biochemistry and Structural Biology
Faculty
Faculty of Health Sciences
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Abstract
This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet. The interaction of the xenobiotics with stearate desaturase was assessed by monitoring their effects on the redox steady state of hepatic microsomal cytochrome b₅, in the presence and absence of cyanide.
Description
Keywords
Microsomes, Liver
Stearic acids
Anaesthetics

Reference:

Manca, V. 1980. The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase. University of Cape Town.

Collections
PhD / Doctoral