50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens

Journal Article

2015

Permanent link to this Item
http://dx.doi.org/10.1371/journal.ppat.1005198
 http://hdl.handle.net/11427/16950
Files
Schwartz_50_Years_of_Emmonsia_Disease_2015.pdf (1.55 MB)
Authors
Schwartz, Ilan S
Kenyon, Chris
Botha, Alfred
Stchigel, Alberto M
De Hoog, G Sybren
Feng, Peiying
Govender, Nelesh P
Dukik, Karolina
Sigler, Lynne
Jiang, Yanping
Stielow, J Benjamin
Muñoz, José F
Cuomo, Christina A
Journal Title

PLoS One

Link to Journal
http://journals.plos.org/plospathogens
Journal ISSN
Volume Title
Publisher

Public Library of Science

Publisher

University of Cape Town

Department
Institute of Infectious Disease and Molecular Medicine
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/4.0

Series
Abstract
New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency.
Description
Keywords
Fungi
Biopsy
Fungal diseases
Fungal structure
Yeast infections
Animal phylogenetics
Fungal pathogens
Respiratory infections

Reference:

Schwartz, I. S., Kenyon, C., Feng, P., Govender, N. P., Dukik, K., Sigler, L., ... & Botha, A. (2015). 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. PLoS Pathog, 11(11), e1005198. doi:10.1371/journal.ppat.1005198

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