Browsing by Subject "HIV-1 vaccines"

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    Open Access
    A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination
    (BioMed Central Ltd, 2012) Chege, GK; Burgers, W; Muller, T; Shephard, EG; Williamson, C; Williamson, A
    We have previously reported induction of robust immune responses in rhesus macaques following a prime boost immunization with candidate HIV-1 vaccines, SAAVI DNA-C (DNA) and SAAVI MVA-C (MVA). These vaccines are already in clinical evaluation. In the current study, we investigated whether re-boosting these animals with a single MVA inoculation after more than 3 years was sufficient to restore previous magnitudes of HIV-specific immune responses.