A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination

Journal Article

2012

Permanent link to this Item
http://hdl.handle.net/11427/15048
 http://dx.doi.org/10.1186/1742-4690-9-S2-P32
Files
Chege_A_single_dose_2012.pdf (163.41 KB)
Authors
Chege, GK
Burgers, W
Muller, T
Shephard, EG
Williamson, C
Williamson, A
Journal Title

Retrovirology

Link to Journal
http://www.retrovirology.com/
Journal ISSN
Volume Title
Publisher

BioMed Central Ltd

Publisher

University of Cape Town

Department
Division of Virology
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/2.0

Series
Abstract
We have previously reported induction of robust immune responses in rhesus macaques following a prime boost immunization with candidate HIV-1 vaccines, SAAVI DNA-C (DNA) and SAAVI MVA-C (MVA). These vaccines are already in clinical evaluation. In the current study, we investigated whether re-boosting these animals with a single MVA inoculation after more than 3 years was sufficient to restore previous magnitudes of HIV-specific immune responses.
Description
Keywords
immune responses
rhesus macaques
prime boost immunization
HIV-1 vaccines
SAAVI DNA-C (DNA)
SAAVI MVA-C (MVA)

Reference:

Chege, G. K., Burgers, W., Muller, T., Shephard, E. G., Williamson, C., & Williamson, A. (2012). A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination. Retrovirology, 9(Suppl 2), P32.

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