Browsing by Author "Zungu, Makhosazane"

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    Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
    (2007) Zungu, Makhosazane; Essop, M Faadiel
    The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.