Browsing by Author "Yorke, Selwyn"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Open Access
    Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'
    (1987) Ramdohr, Jurgen Ernst; Green, Ivan Robert; Yorke, Selwyn
    Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative.