OpenUCT :: Browsing by Author "Wehmeyer, Lance"

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Open Access
The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
(2015) Wehmeyer, Lance; Hapgood, Janet P
Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) crosstalk and explored the mechanism involved in the mouse pituitary gonadotrope LβT2 cell line by dexamethasone (Dex), GnRH and both together.
Open Access
Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
(2010) Wehmeyer, Lance; Hapgood, Janet P; Kotitschke, Andrea
A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for the effects of stress on reproduction. The present study investigated whether this crosstalk between the GR and GnRHR involves the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciprocally modulate each other’s signaling pathways.