Browsing by Author "Salo, Alex"

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    The role of the CCR5 co-receptor conformation in HIV fusion
    (2008) Salo, Alex; Flanagan, Colleen
    This thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.