Browsing by Author "Govender, Preshendren"

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    Development of new bioorganometallic metallodendrimers as in vitro anticancer agents
    (2014) Govender, Preshendren; Smith, Gregory S
    The clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study was to synthesize and characterize a series of polynuclear transition-metal-containing complexes based on a (poly)propyleneimine dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes.
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    Synthesis, characterization and anticancer studies of multinuclear ruthenium(II) arene complexes based on a dendritic scaffold
    (2010) Govender, Preshendren; Smith, Gregory S
    A series of monodentate (N-) and chelating bidentate (N,N-, N,O-), monomeric and dendritic ligands based on a poly(propyleneimine) dendrimer scaffold were synthesized via Schiff base condensation reactions of the relevant amine and appropriate aldehydes. These reactions yielded air- and moisture-stable oils or solids. These ligands contained pyridyl-imine moieties and salicylaldimine moieties. These compounds were isolated in good yields and characterized using standard spectroscopic and spectrometric, analytical techniques.