Browsing by Author "Coert, Claudette"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Open Access
    A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae
    (2002) Coert, Claudette
    It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity.