Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

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dc.contributor.authorGhidelli-Disse, Sonjaen_ZA
dc.contributor.authorLafuente-Monasterio, Mariaen_ZA
dc.contributor.authorWaterson, Daviden_ZA
dc.contributor.authorWitty, Michaelen_ZA
dc.contributor.authorYounis, Yassiren_ZA
dc.contributor.authorPaquet, Tanyaen_ZA
dc.contributor.authorStreet, Leslieen_ZA
dc.contributor.authorChibale, Kellyen_ZA
dc.contributor.authorGamo-Benito, Franciscoen_ZA
dc.contributor.authorBantscheff, Marcusen_ZA
dc.contributor.authorDrewes, Gerarden_ZA
dc.date.accessioned2015-11-27T09:35:20Z
dc.date.available2015-11-27T09:35:20Z
dc.date.issued2014en_ZA
dc.description.abstractMost antimalarial drugs face decreased efficacy due to the emergence of resistant parasites. Therefore, the discovery of new antimalarial medicines is focused on new drugs that act by novel mechanisms and are active against different P. falciparum development stages. Screening of a focused compound library for antiparasitic activity, lead to identification of a novel class of compounds with activity against P. falciparum, 2-aminopyridines. The selected hits were validated and subjected to a lead optimization program resulting in the pre-clinical candidate MMV390048. Here we report an unbiased chemoproteomics strategy for the identification of targets of MMV390048.en_ZA
dc.identifier.apacitationGhidelli-Disse, S., Lafuente-Monasterio, M., Waterson, D., Witty, M., Younis, Y., Paquet, T., ... Drewes, G. (2014). Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. <i>Malaria Journal</i>, http://hdl.handle.net/11427/15411en_ZA
dc.identifier.chicagocitationGhidelli-Disse, Sonja, Maria Lafuente-Monasterio, David Waterson, Michael Witty, Yassir Younis, Tanya Paquet, Leslie Street, et al "Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics." <i>Malaria Journal</i> (2014) http://hdl.handle.net/11427/15411en_ZA
dc.identifier.citationGhidelli-Disse, S., Lafuente-Monasterio, M. J., Waterson, D., Witty, M., Younis, Y., Paquet, T., ... & Drewes, G. (2013). Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. Malaria Journal, 13(Suppl 1), P38-P38.en_ZA
dc.identifier.ris TY - Journal Article AU - Ghidelli-Disse, Sonja AU - Lafuente-Monasterio, Maria AU - Waterson, David AU - Witty, Michael AU - Younis, Yassir AU - Paquet, Tanya AU - Street, Leslie AU - Chibale, Kelly AU - Gamo-Benito, Francisco AU - Bantscheff, Marcus AU - Drewes, Gerard AB - Most antimalarial drugs face decreased efficacy due to the emergence of resistant parasites. Therefore, the discovery of new antimalarial medicines is focused on new drugs that act by novel mechanisms and are active against different P. falciparum development stages. Screening of a focused compound library for antiparasitic activity, lead to identification of a novel class of compounds with activity against P. falciparum, 2-aminopyridines. The selected hits were validated and subjected to a lead optimization program resulting in the pre-clinical candidate MMV390048. Here we report an unbiased chemoproteomics strategy for the identification of targets of MMV390048. DA - 2014 DB - OpenUCT DO - 10.1186/1475-2875-13-S1-P38 DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics TI - Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics UR - http://hdl.handle.net/11427/15411 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15411
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2875-13-S1-P38
dc.identifier.vancouvercitationGhidelli-Disse S, Lafuente-Monasterio M, Waterson D, Witty M, Younis Y, Paquet T, et al. Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics. Malaria Journal. 2014; http://hdl.handle.net/11427/15411.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2014 Ghidelli-Disse et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0.en_ZA
dc.sourceMalaria Journalen_ZA
dc.source.urihttp://www.malariajournal.com/en_ZA
dc.subject.otherantimalarial drugsen_ZA
dc.subject.otherresistant parasitesen_ZA
dc.titleIdentification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomicsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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