Radiological differences between HIV-positive and HIV-negative children with cholesteatoma

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dc.contributor.advisorHarris, Tashneemen_ZA
dc.contributor.advisorFagan, Johannes Jen_ZA
dc.contributor.authorMc Guire, Jessica Kateen_ZA
dc.date.accessioned2018-02-09T07:26:04Z
dc.date.available2018-02-09T07:26:04Z
dc.date.issued2017en_ZA
dc.description.abstractIntroduction: HIV-positive children are possibly more prone to developing cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in patients with HIV and this may predispose HIV-positive children to developing cholesteatoma. There are no studies that describe the radiological morphology of the middle ear cleft in HIV-positive compared to HIV-negative children with cholesteatoma. Aim: Compare the radiological differences of the middle ear cleft in HIV-positive and HIV-negative children with cholesteatoma. Method A retrospective, cross-sectional, observational analytical review of patients with cholesteatoma at Red Cross War Memorial Children's Hospital over a 6 year period. Results: Forty patients were included in the study, 11 of whom had bilateral cholesteatoma and therefore 51 ears were eligible for our evaluation. HIV-positive patients had smaller (p=0.02) mastoid air cell systems (MACS). Forty percent of HIV-positive patients had sclerotic mastoids, whereas the rate was 3% in HIV-negative ears (p<0.02). Eighty-two percent of the HIV-positive patients had bilateral cholesteatoma compared to 7% of the control group (p<0.02). There was no difference between the 2 groups with regards to aeration of the middle ear cleft, bony erosion of middle ear structures, Eustachian tube obstruction or soft tissue occlusion of the post-nasal space. Conclusion: HIV-positive paediatric patients with cholesteatoma are more likely to have smaller, sclerotic mastoids compared to HIV-negative patients. They are significantly more likely to have bilateral cholesteatoma. This may have implications in terms of surveillance of HIV-positive children, as well as, an approach to management, recurrence and follow-up. HIV infection should be flagged as a risk factor for developing cholesteatoma.en_ZA
dc.identifier.apacitationMc Guire, J. K. (2017). <i>Radiological differences between HIV-positive and HIV-negative children with cholesteatoma</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology. Retrieved from http://hdl.handle.net/11427/27435en_ZA
dc.identifier.chicagocitationMc Guire, Jessica Kate. <i>"Radiological differences between HIV-positive and HIV-negative children with cholesteatoma."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology, 2017. http://hdl.handle.net/11427/27435en_ZA
dc.identifier.citationMc Guire, J. 2017. Radiological differences between HIV-positive and HIV-negative children with cholesteatoma. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mc Guire, Jessica Kate AB - Introduction: HIV-positive children are possibly more prone to developing cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in patients with HIV and this may predispose HIV-positive children to developing cholesteatoma. There are no studies that describe the radiological morphology of the middle ear cleft in HIV-positive compared to HIV-negative children with cholesteatoma. Aim: Compare the radiological differences of the middle ear cleft in HIV-positive and HIV-negative children with cholesteatoma. Method A retrospective, cross-sectional, observational analytical review of patients with cholesteatoma at Red Cross War Memorial Children's Hospital over a 6 year period. Results: Forty patients were included in the study, 11 of whom had bilateral cholesteatoma and therefore 51 ears were eligible for our evaluation. HIV-positive patients had smaller (p=0.02) mastoid air cell systems (MACS). Forty percent of HIV-positive patients had sclerotic mastoids, whereas the rate was 3% in HIV-negative ears (p<0.02). Eighty-two percent of the HIV-positive patients had bilateral cholesteatoma compared to 7% of the control group (p<0.02). There was no difference between the 2 groups with regards to aeration of the middle ear cleft, bony erosion of middle ear structures, Eustachian tube obstruction or soft tissue occlusion of the post-nasal space. Conclusion: HIV-positive paediatric patients with cholesteatoma are more likely to have smaller, sclerotic mastoids compared to HIV-negative patients. They are significantly more likely to have bilateral cholesteatoma. This may have implications in terms of surveillance of HIV-positive children, as well as, an approach to management, recurrence and follow-up. HIV infection should be flagged as a risk factor for developing cholesteatoma. DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Radiological differences between HIV-positive and HIV-negative children with cholesteatoma TI - Radiological differences between HIV-positive and HIV-negative children with cholesteatoma UR - http://hdl.handle.net/11427/27435 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27435
dc.identifier.vancouvercitationMc Guire JK. Radiological differences between HIV-positive and HIV-negative children with cholesteatoma. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Otorhinolaryngology, 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27435en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Otorhinolaryngologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherOtorhinolaryngologyen_ZA
dc.titleRadiological differences between HIV-positive and HIV-negative children with cholesteatomaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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