Liver transient elastography values in healthy South African children

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dc.contributor.authorRose, Penelope C.
dc.contributor.authorCotton, Mark F.
dc.contributor.authorOtwombe, Kennedy
dc.contributor.authorInnes, Steve
dc.contributor.authorNel, Etienne D.
dc.date.accessioned2023-08-14T09:05:25Z
dc.date.available2023-08-14T09:05:25Z
dc.date.issued2023-07-13
dc.date.updated2023-07-16T03:12:48Z
dc.description.abstractAbstract Background Transient elastography (TE) is a rapid noninvasive ultrasound-based technology that measures liver stiffness as a surrogate for liver fibrosis and controlled attenuation parameter (CAP) as a measure of liver steatosis. However, normal ranges in children are not well defined in all populations. The aim of this study was to determine transient elastography values in healthy South African children. Methods From April 2019 to December 2021, children were recruited from the HIV negative control group of a cohort study. Only children neither overweight nor obese, without evidence of liver disease, no medical condition or medication associated with hepatic steatosis or fibrosis and normal metabolic profile were included in this cross-sectional analysis. Clinical data, anthropometry and blood samples were collected on the same day as transient elastography with controlled attenuation parameter was performed. Results 104 children (median age 12.8 years [IQR 11.4–14.8, range 7.9–17.7 years]; 59 [57%] boys) were included. Liver stiffness was positively correlated with age (Pearson’s r = 0.39, p < 0.001). Median liver stiffness in boys (5.2 kPa [5th to 95th percentiles 3.6 to 6.8 kPa]) was greater than in girls (4.6 kPa [5th to 95th percentiles 3.6 to 6.1 kPa; p = 0.004]), but there was no difference by ethnicity. Median CAP was 179dB/m (5th to 95th percentiles 158 to 233dB/m). There was a positive correlation between CAP and body mass index (BMI) z-score, but no difference by age, sex, ethnicity or pubertal status. Conclusion Liver stiffness values increase with age and are higher in healthy South African boys than girls, whereas CAP values vary with BMI, but not with age or sex.en_US
dc.identifier.apacitationRose, Penelope C., Cotton, Mark F., Otwombe, K., Innes, S., & Nel, Etienne D. (2023). Liver transient elastography values in healthy South African children. <i>BMC Pediatrics</i>, 23(1), 355. http://hdl.handle.net/11427/38225en_ZA
dc.identifier.chicagocitationRose, Penelope C., Mark F. Cotton, Kennedy Otwombe, Steve Innes, and Etienne D. Nel "Liver transient elastography values in healthy South African children." <i>BMC Pediatrics</i> 23, 1. (2023): 355. http://hdl.handle.net/11427/38225en_ZA
dc.identifier.citationRose, Penelope C., Cotton, Mark F., Otwombe, K., Innes, S. & Nel, Etienne D. 2023. Liver transient elastography values in healthy South African children. <i>BMC Pediatrics.</i> 23(1):355. http://hdl.handle.net/11427/38225en_ZA
dc.identifier.ris TY - Journal Article AU - Rose, Penelope C. AU - Cotton, Mark F. AU - Otwombe, Kennedy AU - Innes, Steve AU - Nel, Etienne D. AB - Abstract Background Transient elastography (TE) is a rapid noninvasive ultrasound-based technology that measures liver stiffness as a surrogate for liver fibrosis and controlled attenuation parameter (CAP) as a measure of liver steatosis. However, normal ranges in children are not well defined in all populations. The aim of this study was to determine transient elastography values in healthy South African children. Methods From April 2019 to December 2021, children were recruited from the HIV negative control group of a cohort study. Only children neither overweight nor obese, without evidence of liver disease, no medical condition or medication associated with hepatic steatosis or fibrosis and normal metabolic profile were included in this cross-sectional analysis. Clinical data, anthropometry and blood samples were collected on the same day as transient elastography with controlled attenuation parameter was performed. Results 104 children (median age 12.8 years [IQR 11.4–14.8, range 7.9–17.7 years]; 59 [57%] boys) were included. Liver stiffness was positively correlated with age (Pearson’s r = 0.39, p < 0.001). Median liver stiffness in boys (5.2 kPa [5th to 95th percentiles 3.6 to 6.8 kPa]) was greater than in girls (4.6 kPa [5th to 95th percentiles 3.6 to 6.1 kPa; p = 0.004]), but there was no difference by ethnicity. Median CAP was 179dB/m (5th to 95th percentiles 158 to 233dB/m). There was a positive correlation between CAP and body mass index (BMI) z-score, but no difference by age, sex, ethnicity or pubertal status. Conclusion Liver stiffness values increase with age and are higher in healthy South African boys than girls, whereas CAP values vary with BMI, but not with age or sex. DA - 2023-07-13 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Pediatrics KW - Liver KW - Fibrosis KW - Paediatric KW - Hepatic KW - Normal LK - https://open.uct.ac.za PY - 2023 T1 - Liver transient elastography values in healthy South African children TI - Liver transient elastography values in healthy South African children UR - http://hdl.handle.net/11427/38225 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12887-023-04170-3
dc.identifier.urihttp://hdl.handle.net/11427/38225
dc.identifier.vancouvercitationRose Penelope C, Cotton Mark F, Otwombe K, Innes S, Nel Etienne D. Liver transient elastography values in healthy South African children. BMC Pediatrics. 2023;23(1):355. http://hdl.handle.net/11427/38225.en_ZA
dc.language.rfc3066en
dc.publisher.departmentDesmond Tutu HIV Centreen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBMC Pediatrics
dc.source.journalissue1en_US
dc.source.journalvolume23en_US
dc.source.pagination355en_US
dc.source.urihttps://bmcpediatr.biomedcentral.com/
dc.subjectLiveren_US
dc.subjectFibrosisen_US
dc.subjectPaediatricen_US
dc.subjectHepaticen_US
dc.subjectNormalen_US
dc.titleLiver transient elastography values in healthy South African childrenen_US
dc.typeJournal Articleen_US
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