Outcome of HIV-exposed uninfected children undergoing surgery

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dc.contributor.authorKarpelowsky, Jonathanen_ZA
dc.contributor.authorMillar, Alastairen_ZA
dc.contributor.authorvan der Graaf, Nellekeen_ZA
dc.contributor.authorvan Bogerijen, Guidoen_ZA
dc.contributor.authorZar, Heatheren_ZA
dc.date.accessioned2015-10-30T09:30:19Z
dc.date.available2015-10-30T09:30:19Z
dc.date.issued2011en_ZA
dc.description.abstractBACKGROUND:HIV-exposed uninfected (HIVe) children are a rapidly growing population that may be at an increased risk of illness compared to HIV-unexposed children (HIVn). The aim of this study was to investigate the morbidity and mortality of HIVe compared to both HIVn and HIV-infected (HIVi) children after a general surgical procedure. METHODS: A prospective study of children less than 60 months of age undergoing general surgery at a paediatric referral hospital from July 2004 to July 2008 inclusive. Children underwent age-definitive HIV testing and were followed up post operatively for the development of complications, length of stay and mortality. RESULTS: Three hundred and eighty children were enrolled; 4 died and 11 were lost to follow up prior to HIV testing, thus 365 children were included. Of these, 38(10.4%) were HIVe, 245(67.1%) were HIVn and 82(22.5%) were HIVi children.The overall mortality was low, with 2(5.2%) deaths in the HIVe group, 0 in the HIVn group and 6(7.3%) in the HIVi group (p = 0.0003). HIVe had a longer stay than HIVn children (3 (2-7) vs. 2 (1-4) days p = 0.02). There was no significant difference in length of stay between the HIVe and HIVi groups. HIVe children had a higher rate of complications compared to HIVn children, (9 (23.7%) vs. 14(5.7%) (RR 3.8(2.1-7) p < 0.0001) but a similar rate of complications compared to HIVi children 34 (41.5%) (RR = 0.6 (0.3-1.1) p = 0.06). CONCLUSION: HIVe children have a higher risk of developing complications and mortality after surgery compared to HIVn children. However, the risk of complications is lower than that of HIVi children.en_ZA
dc.identifier.apacitationKarpelowsky, J., Millar, A., van der Graaf, N., van Bogerijen, G., & Zar, H. (2011). Outcome of HIV-exposed uninfected children undergoing surgery. <i>BMC Pediatrics</i>, http://hdl.handle.net/11427/14507en_ZA
dc.identifier.chicagocitationKarpelowsky, Jonathan, Alastair Millar, Nelleke van der Graaf, Guido van Bogerijen, and Heather Zar "Outcome of HIV-exposed uninfected children undergoing surgery." <i>BMC Pediatrics</i> (2011) http://hdl.handle.net/11427/14507en_ZA
dc.identifier.citationKarpelowsky, J. S., Millar, A. J., van der Graaf, N., van Bogerijen, G., & Zar, H. J. (2011). Outcome of HIV-exposed uninfected children undergoing surgery. BMC pediatrics, 11(1), 69.en_ZA
dc.identifier.ris TY - Journal Article AU - Karpelowsky, Jonathan AU - Millar, Alastair AU - van der Graaf, Nelleke AU - van Bogerijen, Guido AU - Zar, Heather AB - BACKGROUND:HIV-exposed uninfected (HIVe) children are a rapidly growing population that may be at an increased risk of illness compared to HIV-unexposed children (HIVn). The aim of this study was to investigate the morbidity and mortality of HIVe compared to both HIVn and HIV-infected (HIVi) children after a general surgical procedure. METHODS: A prospective study of children less than 60 months of age undergoing general surgery at a paediatric referral hospital from July 2004 to July 2008 inclusive. Children underwent age-definitive HIV testing and were followed up post operatively for the development of complications, length of stay and mortality. RESULTS: Three hundred and eighty children were enrolled; 4 died and 11 were lost to follow up prior to HIV testing, thus 365 children were included. Of these, 38(10.4%) were HIVe, 245(67.1%) were HIVn and 82(22.5%) were HIVi children.The overall mortality was low, with 2(5.2%) deaths in the HIVe group, 0 in the HIVn group and 6(7.3%) in the HIVi group (p = 0.0003). HIVe had a longer stay than HIVn children (3 (2-7) vs. 2 (1-4) days p = 0.02). There was no significant difference in length of stay between the HIVe and HIVi groups. HIVe children had a higher rate of complications compared to HIVn children, (9 (23.7%) vs. 14(5.7%) (RR 3.8(2.1-7) p < 0.0001) but a similar rate of complications compared to HIVi children 34 (41.5%) (RR = 0.6 (0.3-1.1) p = 0.06). CONCLUSION: HIVe children have a higher risk of developing complications and mortality after surgery compared to HIVn children. However, the risk of complications is lower than that of HIVi children. DA - 2011 DB - OpenUCT DO - 10.1186/1471-2431-11-69 DP - University of Cape Town J1 - BMC Pediatrics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Outcome of HIV-exposed uninfected children undergoing surgery TI - Outcome of HIV-exposed uninfected children undergoing surgery UR - http://hdl.handle.net/11427/14507 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14507
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2431-11-69
dc.identifier.vancouvercitationKarpelowsky J, Millar A, van der Graaf N, van Bogerijen G, Zar H. Outcome of HIV-exposed uninfected children undergoing surgery. BMC Pediatrics. 2011; http://hdl.handle.net/11427/14507.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Paediatric Surgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Karpelowsky et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Pediatricsen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcpediatr/en_ZA
dc.subject.otherHIV Infectionsen_ZA
dc.subject.otherHospital Mortalityen_ZA
dc.subject.otherInfectious Disease Transmissionen_ZA
dc.titleOutcome of HIV-exposed uninfected children undergoing surgeryen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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